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1.

Factors associated with COVID-19-related death using OpenSAFELY.

Williamson, Elizabeth J; Walker, Alex J; Bhaskaran, Krishnan; Bacon, Seb; Bates, Chris; Morton, Caroline E; Curtis, Helen J; Mehrkar, Amir; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; MacKenna, Brian; Tomlinson, Laurie; Douglas, Ian J; Rentsch, Christopher T; Mathur, Rohini; Wong, Angel Y S; Grieve, Richard; Harrison, David; Forbes, Harriet; Schultze, Anna; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Perera, Rafael; Evans, Stephen J W; Smeeth, Liam; Goldacre, Ben.

Nature ; 584(7821): 430-436, 2020 08.

Article in English | MEDLINE | ID: mdl-32640463

2.

OpenSAFELY: The impact of COVID-19 on azathioprine, leflunomide and methotrexate monitoring, and factors associated with change in monitoring rate.

Brown, Andrew D; Fisher, Louis; Curtis, Helen J; Wiedemann, Milan; Hulme, William J; Speed, Victoria; Hopcroft, Lisa E M; Cunningham, Christine; Costello, Ruth E; Galloway, James B; Russell, Mark D; Bechman, Katie; Kurt, Zeyneb; Croker, Richard; Wood, Chris; Walker, Alex J; Schaffer, Andrea L; Bacon, Seb C J; Mehrkar, Amir; Hickman, George; Bates, Chris; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Goldacre, Ben; MacKenna, Brian.

Br J Clin Pharmacol ; 2024 Apr 08.

Article in English | MEDLINE | ID: mdl-38589944

3.

The impact of COVID-19 on medication reviews in English primary care. An OpenSAFELY-TPP analysis of 20 million adult electronic health records.

Wood, Christopher; Speed, Victoria; Fisher, Louis; Curtis, Helen J; Schaffer, Andrea L; Walker, Alex J; Croker, Richard; Brown, Andrew D; Cunningham, Christine; Hulme, William J; Andrews, Colm D; Butler-Cole, Ben F C; Evans, David; Inglesby, Peter; Dillingham, Iain; Bacon, Sebastian C J; Davy, Simon; Ward, Tom; Hickman, George; Bridges, Lucy; O'Dwyer, Thomas; Maude, Steven; Smith, Rebecca M; Mehrkar, Amir; Bates, Chris; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Goldacre, Ben; MacKenna, Brian.

Br J Clin Pharmacol ; 2024 Mar 26.

Article in English | MEDLINE | ID: mdl-38531661

4.

Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England.

Grint, Daniel J; Wing, Kevin; Houlihan, Catherine; Gibbs, Hamish P; Evans, Stephen J W; Williamson, Elizabeth; McDonald, Helen I; Bhaskaran, Krishnan; Evans, David; Walker, Alex J; Hickman, George; Nightingale, Emily; Schultze, Anna; Rentsch, Christopher T; Bates, Chris; Cockburn, Jonathan; Curtis, Helen J; Morton, Caroline E; Bacon, Sebastian; Davy, Simon; Wong, Angel Y S; Mehrkar, Amir; Tomlinson, Laurie; Douglas, Ian J; Mathur, Rohini; MacKenna, Brian; Ingelsby, Peter; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; DeVito, Nicholas J; Hulme, Will; Tazare, John; Smeeth, Liam; Goldacre, Ben; Eggo, Rosalind M.

Clin Infect Dis ; 75(1): e1120-e1127, 2022 08 24.

Article in English | MEDLINE | ID: mdl-34487522

5.

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform.

Bhaskaran, Krishnan; Rentsch, Christopher T; Hickman, George; Hulme, William J; Schultze, Anna; Curtis, Helen J; Wing, Kevin; Warren-Gash, Charlotte; Tomlinson, Laurie; Bates, Chris J; Mathur, Rohini; MacKenna, Brian; Mahalingasivam, Viyaasan; Wong, Angel; Walker, Alex J; Morton, Caroline E; Grint, Daniel; Mehrkar, Amir; Eggo, Rosalind M; Inglesby, Peter; Douglas, Ian J; McDonald, Helen I; Cockburn, Jonathan; Williamson, Elizabeth J; Evans, David; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen Jw; Bacon, Sebastian; Smeeth, Liam; Goldacre, Ben.

PLoS Med ; 19(1): e1003871, 2022 01.

Article in English | MEDLINE | ID: mdl-35077449

6.

Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform.

Mathur, Rohini; Rentsch, Christopher T; Morton, Caroline E; Hulme, William J; Schultze, Anna; MacKenna, Brian; Eggo, Rosalind M; Bhaskaran, Krishnan; Wong, Angel Y S; Williamson, Elizabeth J; Forbes, Harriet; Wing, Kevin; McDonald, Helen I; Bates, Chris; Bacon, Seb; Walker, Alex J; Evans, David; Inglesby, Peter; Mehrkar, Amir; Curtis, Helen J; DeVito, Nicholas J; Croker, Richard; Drysdale, Henry; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Tomlinson, Laurie; Evans, Stephen J W; Grieve, Richard; Harrison, David; Rowan, Kathy; Khunti, Kamlesh; Chaturvedi, Nishi; Smeeth, Liam; Goldacre, Ben.

Lancet ; 397(10286): 1711-1724, 2021 05 08.

Article in English | MEDLINE | ID: mdl-33939953

7.

Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY.

Green, Amelia; Curtis, Helen; Hulme, William; Williamson, Elizabeth; McDonald, Helen; Bhaskaran, Krishnan; Rentsch, Christopher; Schultze, Anna; MacKenna, Brian; Mahalingasivam, Viyaasan; Tomlinson, Laurie; Walker, Alex; Fisher, Louis; Massey, Jon; Andrews, Colm; Hopcroft, Lisa; Morton, Caroline; Croker, Richard; Morley, Jessica; Mehrkar, Amir; Bacon, Seb; Evans, David; Inglesby, Peter; Hickman, George; Ward, Tom; Davy, Simon; Mathur, Rohini; Tazare, John; Eggo, Rosalind; Wing, Kevin; Wong, Angel; Forbes, Harriet; Bates, Chris; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian; Evans, Stephen; Smeeth, Liam; Goldacre, Ben.

BMC Med ; 20(1): 243, 2022 07 05.

Article in English | MEDLINE | ID: mdl-35791013

8.

Recording of 'COVID-19 vaccine declined': a cohort study on 57.9 million National Health Service patients' records in situ using OpenSAFELY, England, 8 December 2020 to 25 May 2021.

Curtis, Helen J; Inglesby, Peter; MacKenna, Brian; Croker, Richard; Hulme, William J; Rentsch, Christopher T; Bhaskaran, Krishnan; Mathur, Rohini; Morton, Caroline E; Bacon, Sebastian Cj; Smith, Rebecca M; Evans, David; Mehrkar, Amir; Tomlinson, Laurie; Walker, Alex J; Bates, Christopher; Hickman, George; Ward, Tom; Morley, Jessica; Cockburn, Jonathan; Davy, Simon; Williamson, Elizabeth J; Eggo, Rosalind M; Parry, John; Hester, Frank; Harper, Sam; O'Hanlon, Shaun; Eavis, Alex; Jarvis, Richard; Avramov, Dima; Griffiths, Paul; Fowles, Aaron; Parkes, Nasreen; Evans, Stephen Jw; Douglas, Ian J; Smeeth, Liam; Goldacre, Ben.

Euro Surveill ; 27(33)2022 08.

Article in English | MEDLINE | ID: mdl-35983770

9.

Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts.

Wong, Angel Ys; MacKenna, Brian; Morton, Caroline E; Schultze, Anna; Walker, Alex J; Bhaskaran, Krishnan; Brown, Jeremy P; Rentsch, Christopher T; Williamson, Elizabeth; Drysdale, Henry; Croker, Richard; Bacon, Seb; Hulme, William; Bates, Chris; Curtis, Helen J; Mehrkar, Amir; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; Tomlinson, Laurie; Mathur, Rohini; Wing, Kevin; Forbes, Harriet; Eggo, Rosalind M; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen Jw; Smeeth, Liam; Douglas, Ian J; Goldacre, Ben.

Ann Rheum Dis ; 80(7): 943-951, 2021 07.

Article in English | MEDLINE | ID: mdl-33478953

10.

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.

Grint, Daniel J; Wing, Kevin; Williamson, Elizabeth; McDonald, Helen I; Bhaskaran, Krishnan; Evans, David; Evans, Stephen Jw; Walker, Alex J; Hickman, George; Nightingale, Emily; Schultze, Anna; Rentsch, Christopher T; Bates, Chris; Cockburn, Jonathan; Curtis, Helen J; Morton, Caroline E; Bacon, Sebastian; Davy, Simon; Wong, Angel Ys; Mehrkar, Amir; Tomlinson, Laurie; Douglas, Ian J; Mathur, Rohini; Blomquist, Paula; MacKenna, Brian; Ingelsby, Peter; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; DeVito, Nicholas J; Hulme, Will; Tazare, John; Goldacre, Ben; Smeeth, Liam; Eggo, Rosalind M.

Euro Surveill ; 26(11)2021 03.

Article in English | MEDLINE | ID: mdl-33739254

11.

First dose COVID-19 vaccine coverage amongst adolescents and children in England: an analysis of 3.21 million patients' primary care records in situ using OpenSAFELY.

Hopcroft, Lisa E; Curtis, Helen J; Brown, Andrew D; Hulme, William J; Andrews, Colm D; Morton, Caroline E; Inglesby, Peter; Morley, Jessica; Mehrkar, Amir; Bacon, Sebastian C; Eggo, Rosalind M; Mahalingasivam, Viyaasan; Parker, Edward P K; Tomlinson, Laurie A; Bates, Christopher; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Goldacre, Ben; Walker, Alex J; MacKenna, Brian.

Wellcome Open Res ; 8: 70, 2023.

Article in English | MEDLINE | ID: mdl-37346822

12.

Comparative effectiveness of nirmatrelvir/ritonavir versus sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in non-hospitalised high-risk patients during Omicron waves: observational cohort study using the OpenSAFELY platform.

Zheng, Bang; Tazare, John; Nab, Linda; Green, Amelia Ca; Curtis, Helen J; Mahalingasivam, Viyaasan; Herrett, Emily L; Costello, Ruth E; Eggo, Rosalind M; Speed, Victoria; Bacon, Sebastian Cj; Bates, Christopher; Parry, John; Cockburn, Jonathan; Hester, Frank; Harper, Sam; Schaffer, Andrea L; Hulme, William J; Mehrkar, Amir; Evans, Stephen Jw; MacKenna, Brian; Goldacre, Ben; Douglas, Ian J; Tomlinson, Laurie A.

Lancet Reg Health Eur ; 34: 100741, 2023 Nov.

Article in English | MEDLINE | ID: mdl-37927438

13.

Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study.

Parker, Edward Pk; Tazare, John; Hulme, William J; Bates, Christopher; Carr, Edward J; Cockburn, Jonathan; Curtis, Helen J; Fisher, Louis; Green, Amelia Ca; Harper, Sam; Hester, Frank; Horne, Elsie Mf; Loud, Fiona; Lyon, Susan; Mahalingasivam, Viyaasan; Mehrkar, Amir; Nab, Linda; Parry, John; Santhakumaran, Shalini; Steenkamp, Retha; Sterne, Jonathan Ac; Walker, Alex J; Williamson, Elizabeth J; Willicombe, Michelle; Zheng, Bang; Goldacre, Ben; Nitsch, Dorothea; Tomlinson, Laurie A.

BMJ Open ; 13(1): e066164, 2023 01 31.

Article in English | MEDLINE | ID: mdl-36720568

14.

Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform.

Nab, Linda; Parker, Edward P K; Andrews, Colm D; Hulme, William J; Fisher, Louis; Morley, Jessica; Mehrkar, Amir; MacKenna, Brian; Inglesby, Peter; Morton, Caroline E; Bacon, Sebastian C J; Hickman, George; Evans, David; Ward, Tom; Smith, Rebecca M; Davy, Simon; Dillingham, Iain; Maude, Steven; Butler-Cole, Ben F C; O'Dwyer, Thomas; Stables, Catherine L; Bridges, Lucy; Bates, Christopher; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Zheng, Bang; Williamson, Elizabeth J; Eggo, Rosalind M; Evans, Stephen J W; Goldacre, Ben; Tomlinson, Laurie A; Walker, Alex J.

Lancet Public Health ; 8(5): e364-e377, 2023 05.

Article in English | MEDLINE | ID: mdl-37120260

15.

Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics.

Fisher, Louis; Hopcroft, Lisa Em; Rodgers, Sarah; Barrett, James; Oliver, Kerry; Avery, Anthony J; Evans, Dai; Curtis, Helen; Croker, Richard; Macdonald, Orla; Morley, Jessica; Mehrkar, Amir; Bacon, Sebastian; Davy, Simon; Dillingham, Iain; Evans, David; Hickman, George; Inglesby, Peter; Morton, Caroline E; Smith, Becky; Ward, Tom; Hulme, William; Green, Amelia; Massey, Jon; Walker, Alex J; Bates, Christopher; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; O'Hanlon, Shaun; Eavis, Alex; Jarvis, Richard; Avramov, Dima; Griffiths, Paul; Fowles, Aaron; Parkes, Nasreen; Goldacre, Ben; MacKenna, Brian.

BMJ Med ; 2(1): e000392, 2023.

Article in English | MEDLINE | ID: mdl-37303488

16.

Impact of the COVID-19 pandemic on antipsychotic prescribing in individuals with autism, dementia, learning disability, serious mental illness or living in a care home: a federated analysis of 59 million patients' primary care records in situ using OpenSAFELY.

Macdonald, Orla; Green, Amelia; Walker, Alex; Curtis, Helen; Croker, Richard; Brown, Andrew; Butler-Cole, Ben; Andrews, Colm; Massey, Jon; Inglesby, Peter; Morton, Caroline; Fisher, Louis; Morley, Jessica; Mehrkar, Amir; Bacon, Sebastian; Davy, Simon; Evans, David; Dillingham, Iain; Ward, Tom; Hulme, William; Bates, Chris; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; O'Hanlon, Shaun; Eavis, Alex; Jarvis, Richard; Avramov, Dima; Parkes, Nasreen; Wood, Ian; Goldacre, Ben; Mackenna, Brian.

BMJ Ment Health ; 26(1)2023 Sep.

Article in English | MEDLINE | ID: mdl-37714668

17.

Trends, variation, and clinical characteristics of recipients of antiviral drugs and neutralising monoclonal antibodies for covid-19 in community settings: retrospective, descriptive cohort study of 23.4 million people in OpenSAFELY.

Green, Amelia C A; Curtis, Helen J; Higgins, Rose; Nab, Linda; Mahalingasivam, Viyaasan; Smith, Rebecca M; Mehrkar, Amir; Inglesby, Peter; Drysdale, Henry; DeVito, Nicholas J; Croker, Richard; Rentsch, Christopher T; Bhaskaran, Krishnan; Tazare, John; Zheng, Bang; Andrews, Colm D; Bacon, Sebastian C J; Davy, Simon; Dillingham, Iain; Evans, David; Fisher, Louis; Hickman, George; Hopcroft, Lisa E M; Hulme, William J; Massey, Jon; MacDonald, Orla; Morley, Jessica; Morton, Caroline E; Park, Robin Y; Walker, Alex J; Ward, Tom; Wiedemann, Milan; Bates, Christopher; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Evans, Stephen J W; Goldacre, Ben; Tomlinson, Laurie A; MacKenna, Brian.

BMJ Med ; 2(1): e000276, 2023.

Article in English | MEDLINE | ID: mdl-36936265

18.

Eleven key measures for monitoring general practice clinical activity during COVID-19: A retrospective cohort study using 48 million adults' primary care records in England through OpenSAFELY.

Fisher, Louis; Curtis, Helen J; Croker, Richard; Wiedemann, Milan; Speed, Victoria; Wood, Christopher; Brown, Andrew; Hopcroft, Lisa E M; Higgins, Rose; Massey, Jon; Inglesby, Peter; Morton, Caroline E; Walker, Alex J; Morley, Jessica; Mehrkar, Amir; Bacon, Seb; Hickman, George; Macdonald, Orla; Lewis, Tom; Wood, Marion; Myers, Martin; Samuel, Miriam; Conibere, Robin; Baqir, Wasim; Sood, Harpreet; Drury, Charles; Collison, Kiren; Bates, Chris; Evans, David; Dillingham, Iain; Ward, Tom; Davy, Simon; Smith, Rebecca M; Hulme, William; Green, Amelia; Parry, John; Hester, Frank; Harper, Sam; Cockburn, Jonathan; O'Hanlon, Shaun; Eavis, Alex; Jarvis, Richard; Avramov, Dima; Griffiths, Paul; Fowles, Aaron; Parkes, Nasreen; MacKenna, Brian; Goldacre, Ben.

Elife ; 122023 07 27.

Article in English | MEDLINE | ID: mdl-37498081

19.

OpenSAFELY: Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England.

Andrews, Colm; Schultze, Anna; Curtis, Helen; Hulme, William; Tazare, John; Evans, Stephen; Mehrkar, Amir; Bacon, Sebastian; Hickman, George; Bates, Christopher; Parry, John; Hester, Frank; Harper, Sam; Cockburn, Jonathan; Evans, David; Ward, Tom; Davy, Simon; Inglesby, Peter; Goldacre, Ben; MacKenna, Brian; Tomlinson, Laurie; Walker, Alex.

Wellcome Open Res ; 7: 191, 2022.

Article in English | MEDLINE | ID: mdl-35966958

20.

Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe covid-19 outcomes in patients in the community: observational cohort study with the OpenSAFELY platform.

Zheng, Bang; Green, Amelia C A; Tazare, John; Curtis, Helen J; Fisher, Louis; Nab, Linda; Schultze, Anna; Mahalingasivam, Viyaasan; Parker, Edward P K; Hulme, William J; Bacon, Sebastian C J; DeVito, Nicholas J; Bates, Christopher; Evans, David; Inglesby, Peter; Drysdale, Henry; Davy, Simon; Cockburn, Jonathan; Morton, Caroline E; Hickman, George; Ward, Tom; Smith, Rebecca M; Parry, John; Hester, Frank; Harper, Sam; Mehrkar, Amir; Eggo, Rosalind M; Walker, Alex J; Evans, Stephen J W; Douglas, Ian J; MacKenna, Brian; Goldacre, Ben; Tomlinson, Laurie A.

BMJ ; 379: e071932, 2022 11 16.

Article in English | MEDLINE | ID: mdl-36384890

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